Decoding Drug Abuse in Noncoding RNA?

Decoding noncoding RNA: da Vinci redux?

Decoding Noncoding RNA: Da Vinci Redux? Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/CIRCRESAHA.113.301865 2013;113:240-241 Circ Res. http://circres.ahajournals.org/content/113/3/240 World Wide Web at: ...

Noncoding RNA in drug resistant sarcoma

Sarcomas are a group of malignant tumors that arise from mesenchymal origin. Despite significant development of multidisciplinary treatments for sarcoma, survival rates have reached a plateau. Chemotherapy has been extensively used for sarcoma treatment; however, the development of drug resistance is a major obstacle limiting the success of many anticancer agents. Sarcoma biology has traditiona...

Decoding the Long Noncoding RNA During Cardiac Maturation

Study of Long Noncoding RNA FER1L4 and RB1, as Its Competing Endogenous RNA Network Target Gene, in Breast Cancer

Introduction: Breast cancer is the second most common cause of cancer-related death among females, which requires an exploration for markers to propose a more specific categorization of this cancer. Long noncoding RNAs (lncRNAs), the main subset of noncoding transcripts, are involved in tumorigenic processes. In this study, we investigated the expression of the fer-­1–­like family member 4 (FER...

Decoding Noncoding Regulatory DNAs in Metazoan Genomes

The recent revelation that the human genome contains only ~30,000 genes underscores the importance of gene regulation in generating organismal diversity. Cis-regulatory DNAs, or enhancers, are short stretches of DNA--300 bp to 1,000 bp in length--that control gene expression. This DNA accounts for a substantial fraction of metazoan genomes, but is largely invisible. It cannot be identified by s...